The 2001-2002 financial year saw several good outcomes with Blackmores’ products in clinical trials. Trials completed include Blackmores Executive B Stress Formula™, Blackmores BioACE® Excell with Selenium, and a smaller study with Blackmores Hyperiforte®.
The Blackmores Executive B study was an intervention study in persons with work-related stress. It was conducted at the Brain Sciences Institute and Department of Neuropsychopharmacology, University of Swinburne, Victoria.
Another study, also conducted at the Brain Sciences Institute and Department of Neuropsychopharmacology, University of Swinburne, Victoria, compared Blackmores Hyperiforte® to two competitive hypericum products using quantitative human electroencephalography (EEG).
Blackmores had previously conducted a trial with young persons using Blackmores’ original BioACE® Excell and measuring blood markers of antioxidant activity and also heat shock proteins. The study was published in the journal Free Radicals in Biological Medicine in 2000. Another trial was conducted with the newer Blackmores BioACE® Excell with Selenium, this time in older persons, again at the University of New England and also looking at antioxidant status and heat shock protein production.
The results of these studies await publication, and will contribute to the convincing level of evidence validating the efficacy of Blackmores’ formulations.
Listed below are some of the recent publications arising from Blackmores supported research. Coenzyme Q(10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus. Watts, G. F., Playford, D. A., Croft, K. D., Ward, N. C., Mori, T. A., and Burke, V. Diabetologia. 2002;45:420-426 (supply of CoQ10 active and placeboes)
Coenzyme Q(10) improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Hodgson, J. M., Watts, G. F., Playford, D. A., Burke, V., and Croft, K. D. Eur J Clin Nutr. 2002;56:1137-1142. (supply of CoQ10 active and placeboes – see study above)
The acute nootropic effects of Ginkgo biloba in healthy older human subjects: a preliminary investigation. Nathan, P. J., Ricketts, E., Wesnes, K., Mrazek, L., Greville, W., and Stough, C. Human Psychopharmacology. 2002;17:45-49.
An investigation into the acute nootropic effects of Hypericum perforatum L. (St. John's Wort) in healthy human volunteers. Ellis, K. A., Stough, C., Vitetta, L., Heinrich, K., and Nathan, P. J. Behav Pharmacol. 2001;12:173-182.
Neuropsychological changes after 30-day Ginkgo biloba administration in healthy participants. Stough, C., Clarke, J., Lloyd, J., and Nathan, P. J. Int J Neuropsychopharmacol. 2001;4:131-134.
Stress proteins as biomarkers of oxidative stress: effects of antioxidant supplements. Peng, J., Jones, G. L., and Watson, K. Free Radic Biol Med. 6-1-2000;28:1598-1606.
